Wednesday, November 28, 2012

Research Paper First Draft


Chad Allen
Adam Sprague
English 101
28 November 2012
New Discoveries
            Two legally blind women, one suffering from macular degeneration, the other suffering from Stargardt’s macular dystrophy, each received 50,000 embryonic stem cells implanted under the retina of one eye in July of 2011. Both patients reported major improvements in sight. A scientific miracle. Embryonic stem cells are cells derived from a human embryo. Embryonic stem cells are interesting, because they are able to grow into different kinds of specialized cells, which are able to perform many tasks throughout the human body. Because these stem cells come from human embryos, there have been a myriad of ethical issues surrounding the research[M1] . Such issues include the fact that scientists should not be messing with human life, because every living embryonic cell has the potential to become a baby. The debate about abortion is also a similarly related topic to stem cell research. While there is much controversy dealing with the ethics of embryonic stem cell research, there is an endless potential for scientists to learn about cell development, and possibly find a cure to many diseases affecting lives every day.
            When thinking about embryonic stem cell research, it is important to discuss the different arguments that surround it. One major point about any type of stem cell research is that stem cells have the ever-existing possibility to cure diseases and save lives. Another big positive to researching embryonic stem cells is that they have the potential to change medicine forever. Imagine a world where you could get a specific medicine for any symptoms or disease you may have. The research of embryonic stem cells even has the possibility to dig deeper into solving the problem of cancer, and possibly finding solutions. Possibly even a cure. Just like Newton’s 3rd Law of Physics, with every positive aspect surrounding an issue, there are always negatives in return. One negative view about researching embryos in a lab is the issue some people have with pro-life. [M2] Several religious groups are very much against the misuse of a human embryo, and they believe that human life should not be messed with. Regardless, the stem cell debate has been a major issue in the science world, and also a very interesting subject to discuss.
            Before studying the controversy about embryonic stem cell research it is important to understand the background and how they work. After conception, a sperm cell fertilizes an egg and it divides to produce an embryo. Within the embryo, there are numerous stem cells that are capable of becoming various specialized cells useful to many functions the[M3]  human body. For the use of research, scientists receive embryos in two ways. One way to obtain stem cells is with the use of in vitro fertilization. In this process, a couple's sperm and egg cells are fertilized together in a culture dish. The eggs develop into embryos, and then return to the female. Because there are more embryos made than can be implanted, many of the ‘leftovers’ are usually frozen for later use. Many couples who go through this process of in vitro fertilization donate their ‘leftover’ embryos for stem cell research (Bishop[M4] ).
            Another way scientists acquire embryos is through therapeutic cloning. This technique combines a cell with a donor egg. The nucleus is then removed from the donor egg and replaced with the nucleus from the patient's cell. This egg is stimulated to divide, and the resulting embryo holds the patient's genetic material, which is useful because it decreases the chances that the patient’s body will reject the new stem cells. This method is less common, but both methods are seen as controversial to the public (Bishop).
When the cells become three to five days old, the embryo develops into a chunk of cells called a ‘blastocyst,’ as shown in Figure 1. A blastocyst contains about 100 cells; the stem cells are located inside. At this point, the stem cells are pluripotent; they are able to develop into almost any type of specialized cell. To grow these specialized stem cells, scientists remove them from their blastocyst and grow them in a nutrient-rich solution in a Petri dish in a laboratory. After several months, these cells divide infinitely and scientists call these large amounts ‘stem cell lines,’ which can then be frozen for later use (EuroStemCell).
Figure 1: An embryonic stem cell goes through the stages of in vitro [M5] fertilization in order to become a blastocyst, and then later, a specialized cell.
           
            When looking at the consequences of embryonic stem cell research, it is important to look at how people perceive the idea of abortion in society today. The idea of abortion is a difficult issue that many people and politicians run into in their lives. Abortion is viewed my many as bad, because it is the process of ‘killing’ a living organism inside of a woman. Others feel that is should 100% be the woman’s choice whether to have an abortion or not. I believe that embryonic stem cell research is drastically different than abortion when you look at the ethical reasons behind both issues. First of all, abortion is the process of destroying a human embryo, while embryonic stem cell research uses the embryo in every way possible for the soul purpose of research to better the medical world as a whole. Scientists absolutely do not murder embryos when they research them. In order for something good to happen in life, there always has to be minor sacrifices made (Explorable.com).
            One major argument as to why many people oppose the use of embryos for stem cell research goes back to religion. Different religions view the status of a human embryo in several unique ways. For example, the Roman Catholic, Orthodox and conservative Protestant Churches believe that the embryo has the highest status [M7] after conception, and should be treated as a human would be treated. The people who follow these religions believe a human embryo has the right to its own life, and every intervention not in favor of the embryo is a violation of that right. On the other hand, Judaism and Islam believe the importance of helping others and argue that the embryo does not have full human status before 40 days. There are also several other religions that take other less important positions. Overall, religion is a huge counterargument when it comes to dealing with embryonic stem cell research, but once again, if you look at the positives regarding stem cell research, they outweigh the negatives by a landslide. In f[M8] igure 2, a comic is provided to show the humorous side of the argument, and why religion should not be a factor when it comes to dealing with science and medical advancements which could potentially save lives (Hug).

Figure [M9] 2: A comic showing the ridiculousness about why embryonic stem cell research is not allowed and the humor behind the argument.


            One of the sources I found most interesting was that of a book by Erik Parens[M10] , where he talks about specifically the moral difference between research on embryos with the original intention being reproduction, rather than just for research. He illustrates the fact that when you research on embryos for the purpose of reproduction, it does not give off a negative energy. Scientists are researching these embryos to show how they can be useful in the process of reproduction. These scientists are not ‘destroying’ the embryos, but rather growing them for further use. That is a very important point to make, because they are not just researching these precious embryos, they are developing them into possibly something more, which could eventually be used to save lives and cure illnesses (Parens).
            Imagine a life where doctors could cure blindness, as well as many other diseases that affect people every day. Just[M11]  like the two legally bind women previously mentioned, there could be numerous miracles created with the help of embryonic stem cells. There is nothing greater in the world than life, and the fact that these special cells could help save lives is an extraordinary thought. Regardless of the fact that different people disagree with the research of embryonic stem cells, these very cells have the possibility to save lives. To cure the blind, the deaf, the paralyzed. A truly amazing discovery. To be able to turn these embryonic cells into different types of valuable specialized cells is magnificent because they are able to perform functions in the human body that once were not able to be completed. There are many real life stories out in the world where people receive stem cells that benefit them in a life-changing way, and there is nothing better than changing someone’s life for the better. Embryonic stem cells push the limits of cell research, provide exciting discoveries in the medical world, and essentially have the ability to save lives and promote healthy people across the globe. This type of research, producing only positive scenarios, should definitely be legal and appreciated by people around the world. To change a life is truly inspiring, and these scientists are on the right path to doing so[M12] .


Works[M13]  Cited

            With the ever-increasing population in the world, there are, as a result, many diseases that take over our lives. Scientists everywhere are constantly researching many of the diseases that have not yet found a cure. In the early 1960’s, scientists discovered stem cells, cells that could self-renew. Later in the century, stem cell research has been an intriguing subject for scientists around the world. There are a few different types of stem cells: adult cells, fetal cells, cord blood cells, Induced Pluripotent cells, and embryonic cells. Embryonic stem cells are very interesting because they can be specialized to function as any cell in the human body.

            While there is much controversy dealing with the ethics of embryonic stem cell research, there is an endless potential for scientists to learn about cell development, and possibly find a cure to many diseases affecting lives every day. I plan to support my thesis by looking at the benefits of embryonic stem cell research, and also show the counterargument, and why I believe my thesis is more accurate. Yes, there are many ethical issues regarding the process of removing a human embryo for research, and in my paper I am addressing how those concerns are practically irrelevant in the big picture.


Bishop, A. E. and Rippon, H. J. (2004), Embryonic stem cells. Cell Proliferation, 37: 23–34. doi: 10.1111/j.1365-2184.2004.00298.x
This source is a scholarly article written by H. J. Rippon and A. E. Bishop describing how embryonic stem cells work and how they are able to regenerate and possibly create tissues and organs. This article is more about the scientific aspect of embryonic stem cell research, so it is a good source to have to fully understand how stem cells work, and the biological reasoning behind them. I can use this source in my first couple paragraphs because it can be useful to explain how embryonic stem cells work, and then I will able to go into the ethical side of the argument without much confusion. H. J. Rippon and A. E. Bishop are very credible because they are both apart of the Tissue Engineering and Regenerative Medicine Centre in London, UK.

Explorable.com (2008). Stem Cell Research. Retrieved 21 Oct. 2012 from Explorable:             http://explorable.com/stem-cell-pros-and-cons.html
This online source outlines the pros and cons dealing with stem cell research. Explorable.com does a very good job giving both sides of the argument by showing what stem cells are, and by presenting lists that show pros and cons. I learned several diseases that could possibly be treated by use of stem cells, and also how there are several cons, such as the value of human life. I also learned that the pros and cons differed slightly after 2007, scientists have moved on to use more ethical methods for stem cell research, such as iPS. This web page is a good page to use as both an argument for embryonic stem cell research, as well as a counterargument. Explorable.com is run by a group of scientists and psychologists who study many topics, so this is a credible source.

Top of Form
Holland, Suzanne, Karen Lebacqz, and Laurie Zoloth. The Human Embryonic Stem Cell    Debate: Science, Ethics, and Public Policy. Cambridge, Mass: MIT Press, 2001.        Print.
This source was an article by Erik Parens in a book called The Human Embryonic Stem Cell Debate: Science, Ethics, and Public Policy. Parens talks about specifically the moral difference between research on embryos with the original intention being reproduction, rather than just for research. A few facts I found from this book was that there is a concern that scientists sometimes treat embryos as something less of what they should be. Parens also illustrates the concern that women might start to donate their ova for research, which is not the intention of scientists. Paren basically explains how scientists should treat embryos and the moral aspect of retrieving an embryo for research, rather than for reproduction. I plan to use this in my body paragraphs to go into detail on the ethical issue surrounding stem cells, and how embryos are important. Erik Parens is a Senior Research Scholar at The Hastings Center, and he received his doctorate degree at the University of Chicago.

Hug, Kristina. "Embryonic Stem Cell Research: An Ethical Dilemma | Europe's Stem         Cell Hub | EuroStemCell." EuroStemCell. N.p., 23 Mar. 2011. Web. 21 Oct.    2012. <http://www.eurostemcell.org/factsheet/embryonic-stem-cell-         research-ethical-dilemma>.
This is an online article that shows the ethical dilemma behind stem cell research, including the moral status of a human embryo. Kristina Hug gives a variety of opinions people have, and she gives arguments on both sides. Such opinions include that the embryo has full mortal status from fertilization onwards, that embryos have an increasing status as it develops, and also how different religions have different views of the moral value of the human embryo. Hug basically shows how there are many points of view to the human embryo, and shows how people disagree on each issue. This source is an excellent source because it gives both sides of the argument, and also I can look at different religions and see their beliefs on stem cell research. Kristina Hug is a Ph.D. student in the Department of Medical Ethics at Lund University in Sweden.

“A Stem Cell Story.” YouTube.com. 14 June 2011. EuroStemCell. Accessed 21 October 2012. <http://www.youtube.com/watch?feature=player_embedded&v=2-3J6JGN-_Y#!>
            This film was created by EuroStemCell, an online organization that educates people on stem cell research. The main point of this film was to show to the audience what stem cells are, where they come from, and what they can potentially accomplish. I got facts such as the many stages of development of stem cells, and also how one cell can become almost any type of specialized cell. I liked this source because it is a film, and gives very visually appealing facts and information. This source is great for looking at the idea of embryonic stem cell research in a different light, and there are several interviews that I can quote in my paper.

Bottom of Form




 [M1]Your intro is very good, nice job.

 [M2]Rephrase, “issue with pro-life” sounds a bit awkward.

 [M3]“of the”

 [M4]Good explanation, I think this is helpful to readers who may not know a lot about the issue.

 [M5]Formatting errors.  Revisit the sample MLA paper for proper format.

 [M6]You may have a bit too much description and explanation in your paper.

Focus a bit more on your argument. 

Can you trim this down and bring in more sources favoring your position?

 [M7]What do you mean by highest status?

 [M8]Should say:  “Fig. 2”

Format all your references to figures this way in your paper.

 [M9]Youll need to reformat all your captions.

“ridiculousness” is probably too harsh and casual for an academic essay.  Be sensitive to other side.

Make sure to cite your source in these!

 [M10]Titled what? and who is erik ?  Doctor? Professor?  Janitor?

 [M11]I like how you connect your conclusion to your introduction, very nice.

 [M12]Good job, really good job.

A few formatting issues, and I think you provide a bit too much background info in the opening of the paper.

This is close to being ready for your portfolio.

5.7/6

 [M13]This should not be an annotated bib, just a regular Works Cited page – a list of sources.  You’ll need to revise this.